this was so cool hearing @jayrshenoy talk about (it went way over my head) getting to pre-print!!! check it out:
Gordon Wetzstein (@GordonWetzstein)
AlphaFold-based models like Boltz-2 and BioEmu train on atomic conformational structures in order to predict protein dynamics. But is it possible to train these models directly on cryo-EM map ensembles, harnessing conformational data that is typically not deposited in the PDB?
Introducing CryoSampler: a new approach for fine-tuning Boltz-2 with raw supervision on cryo-EM map ensembles.
1/6🧵
Video
— https://nitter.net/GordonWetzstein/status/2054195401876767075#m